Abstract: Under the background of engineering education certification, it is necessary to build a comprehensive practical training course for precision instrument or precision measurement system for undergraduate students majoring in mechanical engineering, intelligent manufacturing, and measurement & control majors. Coordinate measuring machine (CMM) is selected as a practical teaching platform, which is a typical precision instrument integrating “optical, mechanical, electrical and computing”. The measuring practice platform of general measuring software PC-DMIS of CMM and the offline software programming practice teaching platform are built, the teaching objectives for outcomes-based education (OBE) are defined, and the method of teaching goal achievement degree analysis are given. Several rounds of practical courses teaching have been carried out. Through practical training, students can solve complex measurement engineering problems of precision parts, master the application of general measurement software, and get familiar with its special software development. The CMM large-scale instrument practice system teaching based on OBE is helpful to cultivate students’ practice and innovation ability, and can provide reference for the construction of relevant professional practice courses.