Abstract: In order to meet the requirement of durability test of domestic ultrasonic scalpel, a durability test platform of ultrasonic scalpel was designed and manufactured. The platform uses stepping motor to drive the gantry structure composed of ball screw to realize the three-axis translation of ultrasonic knife; uses improved torque closed-loop electric push rod to realize the controllable torque push of ultrasonic knife handle; self-designed fixture which can hold 6 ultrasonic knife heads at the same time, and uses micro-electric push rod to control the excitation of ultrasonic knife. According to the requirement of durability test of ultrasonic knife, each module of the platform is designed and verified. It is proved that the platform can achieve a speed adjustment of 0-1.5 ms, a pressing time adjustment of 0-5000 ms, and a pressing force adjustment of 0-100 N, and stably carry out more than 100,000 durability tests of 6 knives at the same time, and can be used to evaluate the durability of ultrasonic scalpel.