Abstract: Chemicals are necessary for scientific research and experimental teaching in colleges and universities. Because of their various types, complex physical and chemical properties, most of them have the characteristics of flammability, corrosiveness and toxicity, and are important hazards in college laboratories, which must be focused on prevention. Based on the practice of chemical safety management in schools, it is proposed to conduct standardized management in various links such as procurement, storage, use and waste recycling with safety education and policy propaganda as the guide, information platform as the support, and regular special inspection as the supervision, so as to achieve the work goal of “less purchase, less storage, rapid circulation and standardization”, in order to provide reference for the effective management of chemicals in colleges and universities.