Abstract: The increasing use of special equipment accompanying with the research expansion in university laboratory has become one of the important hazards threatening laboratory safety. At the same time, the management of laboratory special equipment in colleges and universities suffers from imperfect management system, few administrative staffs, and lack of process management, which has become a risk threatening the property and life safety of teachers and students in colleges and universities. Through establishing full-time and part-time management positions, setting training courses, organizing forensics examination and applying registration certificate of the “position, course, examination, and certification” safety management mode, it is proved to be of important reference significance to improve the level of college special equipment safety management and realize the life-cycle management.