Abstract: The establishment of a feasible long-term control mechanism for hazardous chemicals is the top priority to realize the normal safety of colleges and university laboratories. According to the risk of hazardous chemicals and its control requirements, in view of the actual problems of the whole process management of hazardous chemicals in laboratories, the danger source control theory is applied. On the basis of improving the management system, clarifying the responsibility system and finding out the base number, the information construction is relied. Through regulating the procurement and storage, controlling the quantity, strengthening the use management and improving the timeliness of disposal, a long-term mechanism is established for the safety control of hazardous chemicals. The education and training is strengthened in daily work as well so as to mobilize the enthusiasm of staff and implement and continuously improve the working mechanism.