Abstract: In recent years, the construction of laboratory safety access system has been paid more and more attention by colleges and universities, which mainly focuses on the safety education access of laboratory personnel, the safety access management of experimental sites, projects and hazardous chemicals. This article from the mode of university laboratory security access management present situation analysis, combined with the actual situation of schools and colleges, this paper puts forward innovation based on the laboratory “customization” security access scheme of risk identification, aims to change the traditional extensive access management for accurate “customization” style of management, the security access management really is more accurate, professional, comprehensive, Laboratory safety hazards are greatly reduced, and the probability of safety accidents is significantly reduced.