Abstract: In recent years, establishing a laboratory safety access system has gained significant attention in colleges and universities. The system mainly focuses on safety education requirements for laboratory personnel, and safety access management of experimental sites, projects and items. Based on an analysis of current modes of laboratory safety access management in universities, combined with the actual situation of schools and colleges, this paper proposes a“customized” safety access protocol based on laboratory risk identification. It aims to shift the traditional extensive access management toward a precise and“customized” management approach, making safety access management more accurate, professional and comprehensive. This approach can reduce laboratory safety hazards and lower the probability of safety accidents.