Abstract: In response to the issues of incomplete, inaccurate, and unscientific identification of risk factors, determination of risk importance, and impact assessment in university laboratory safety management, this study proposes a laboratory risk indicator system and evaluation model based on the Analytic Hierarchy Process (AHP) and Fuzzy Comprehensive Analysis (FCA).By conducting a safety risk factor survey and key factor screening in university laboratories, the Analytic Hierarchy Process (AHP) was applied to develop a laboratory risk indicator system consisting of 7 primary and 36 secondary indicators.The Fuzzy Comprehensive Analysis (FCA) method was used to conduct single-factor fuzzy evaluation and comprehensive fuzzy evaluation.The results show that the importance ranking in university laboratory safety management is as follows: laboratory safety management > responsibility system construction > safety inspection content > chemical safety management > biological safety management > daily site management >mechanical and electrical safety management .Using the Fuzzy Comprehensive Evaluation method, the laboratory safety risk level evaluation matrix Y = (0.2688, 0.4091, 0.2565, 0.0656) was calculated, with the highest membership degree being 0.4091, resulting in a risk evaluation level of Level 2, indicating “general safety condition with some risks.”Based on the risk evaluation results, corresponding risk control measures were developed for the main risk points, providing important references for universities to accurately assess experimental safety risks and laboratory risk classification..