Abstract: The laboratories in universities are important “incubators” of scientific and technological innovation and high-level innovative talent training, and their construction and management levels, to some extent, reflect the innovation and development level of the universities. With the strengthening of “Strategy of Rejuvenating the Country Through Science and Education” in China, the investment of the universities has increased year by year, and the hardware conditions of laboratories, especially the quantity and quality of large instruments and equipment, have been greatly improved. However, the problem of poor laboratory management is still relatively common, which makes it difficult to give full play to the advanced hardware and may also bring about problems in laboratory safety. China Inspection Body and Laboratory Mandatory Approval (CMA), as a mandatory requirement for inspection and testing institutions that “provide notarized data to the society”, is a high-standard and highly operational quality management system that is highly suitable for laboratory management. This article will briefly discuss the positive significance of the CMA system for laboratory management, especially instruments and equipment management, and its classified guidance for different types of laboratories.