Abstract: Under rapidly advancing hardware conditions, university laboratories still generally face issues such as irregular management, untapped efficiency, and potential safety hazards. These problems vary significantly across different types of laboratories and there is a lack of systematic and practical management guidance. Focusing on the functional positioning and operational characteristics of three types of university laboratories—teaching-oriented, research-oriented, and comprehensive service-oriented—this paper introduces the China Inspection Body and Laboratory Mandatory Approval (CMA) management system, systematically analyzing its applicability in laboratory management and exploring its classified guidance paths for different types of laboratories. The research indicates that the CMA system is highly compatible with university laboratory management. Drawing on its management concepts and operational models helps to improve the standardization of laboratory management, effectively reduce the risk of safety incidents, enhance the efficiency of instrument and equipment use, and ensure the accuracy and traceability of experimental data. Meanwhile, the system plays a positive role in promoting high-level talent development and enhancing research service capabilities, providing both theoretical support and practical reference for the construction and management of university laboratories.