Abstract: The management of experimental consumables in colleges and universities is large, difficult to supervise, and involves many functional departments and internal control risk points. By applying COSO internal control framework, this paper studies the experimental consumables management business of S University, analyzes the internal control environment and related risks of business management, and establishes an internal control management model from organizational structure, system construction, process management, information system and other aspects on the basis of risk assessment. And optimize the internal control management from the perspective of service, evaluate the internal control management from the perspective of supervision, and continuously promote the improvement and promotion of internal control. Through the interaction of control objectives, risk assessment and control activities, it is beneficial to achieve a virtuous cycle of internal control, risk management and university governance, and play the supporting role of experimental consumables management in school talent training and scientific research.