Abstract: The lattice structure formed by the orderly arrangement of interconnected nodes and struts possesses the features of light weight, load-bearing and energy absorption, and is widely used in engineering practice. By combining unit cells with different structural configurations to construct the lattice structure, the compression behavior and energy absorption properties of the lattice structure in hybrid configurations are explored. The mechanical response of the structure under uniaxial compressive loading is investigated, and the mechanical properties and deformation modes of the single-configuration structure are compared with those in the hybrid configuration. A quantitative and comprehensive assessment of the energy absorption performance of the lattice structure is performed based on the complex proportional assessment method. The results show that, compared with a single configuration, a rational combination of structural configurations can integrate the functional characteristics of each component configuration, resulting in improved compression performance and more stable and balanced energy absorption performance of the lattice structure in hybrid configuration. The proposed design strategy for constructing hybrid configuration structures can provide theoretical guidance and design basis for the development of novel energy-absorbing structures based on lattice structures.