钛种植体改性及成骨性能研究的综合实验设计

Comprehensive experimental design for the study of modification and osteogenic properties of titanium implants

  • 摘要: 围绕骨修复材料的研究热点,针对钛种植体成骨能力有限的问题,创新性地引入新技术、新材料,设计了一个探索型、创新型综合实验:钛种植体改性及成骨性能研究的综合实验设计。通过电化学沉积的方法,将具有成骨性能的茶多酚还原氧化石墨烯(TPG)沉积于钛种植体上,通过控制不同的沉积时间,获得TPG含量不同的改性钛种植体。此外,通过细胞黏附和增殖实验评估改性钛种植体的成骨性能。结果表明:通过控制沉积时间,成功获得不同含量TPG的改性钛种植体;沉积5 min的改性钛种植体更有利于成骨细胞的黏附,进而促进细胞的增殖,为钛种植体的改性及应用奠定理论研究基础。

     

    Abstract: Focusing on the research focus of bone repair materials and in view of the problem of limited osteogenic ability of titanium implants, an exploratory and innovative comprehensive experiment was designed by introducing new technologies and new materials to study the modification and osteogenic properties of titanium implants. Tea polyphenol functionalized and reduced graphene oxide (TPG) with osteogenic properties was deposited on titanium implants by electrochemical deposition method. Modified titanium implants with different TPG content were obtained by controlling different deposition time. In addition, the osteogenic properties of the modified titanium implants were evaluated by cell adhesion and proliferation experiments. The results showed that modified titanium implants with different TPG content were successfully obtained by controlling the deposition time. The modified titanium implants deposited for 5 minutes are more conducive to the adhesion of osteoblasts and promote the proliferation of cells, which lays a theoretical foundation for the modification and application of titanium implants.

     

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