Abstract: In order to reduce the subjective influence on the comprehensive evaluation of the quality of experimental teaching process, improve the reliability of the comprehensive evaluation of the results of the experiment teaching quality, this model of comprehensive evaluation of experiment teaching quality is established. By introducing matter element analysis theory and applying the AHP analysis method to calculate the weight of every index, the model is used to analyze an example, which further proves the feasibility and effectiveness of the method. This provides new reference methods for the research of comprehensive evaluation of experiment teaching quality in college.