Abstract: Analysis and Design of Information System usually obtains low efficiency causing for the wide scope of knowledge. Directing at the features of the course, a teaching method that gives priority to case-teaching is put forward. Case-teaching as the main line is a teaching method that uses a case at a whole semester, and is assisted by team work, class discussing and achievement presentation. Practice indicates that the threshold of learning is reduced and teaching effect arises after this method implemented. It is helpful to combine theory and practice.