Abstract: With the reform of higher education from theoretic talents to applied talents, it is very important to construct on the practical teaching system for applied and innovative information management talents. To meet the gradual teaching rules and the existing problems in practical teaching of management information system, this paper puts forward the quaternity practice teaching system of integrated curriculum experiment, curriculum project, open experiment and innovative practice. The teaching practice shows that the practice teaching system can effectively cultivate the students’ application ability and innovation ability.