Abstract: The prevent leaking water and anti-theft system of university laboratory has been designed with high performance, low power microprocessor, in conjunction with the peripheral components.The overflow water sensing device and signal control circuit are made. The hardware control software and signal processing software have been programmed. The system is simulated and the determination of actual operation,the results are satisfactory. Due to the adoption of SCM, which makes the system compact, low power consumption, easy to expand the detection point, and can meet the actual demand of laboratory water overflow preventing and anti-theft. In general,the system is stable and reliable, timely alarm, high ratio of performance to price.