Abstract: Large equipment is the essential condition of teaching and scientific research in colleges and universities.How to manage large equipment service teaching and scientific research is a focus of current. This paper from the perspective of my own management thermal analysis instrument, combined with work in the theory of teaching and scientific research experience, from the instrument management, teaching content, teaching mode of the instrument, instrument into the combination of teaching and scientific research, the author summarizes the use of large-scale instruments and the practice of teaching and scientific research.