Abstract: The large laboratory instruments are the very important parts in research and social services of the colleges and research institutions.If the new instrument from the beginning to be under the strengthen and scientific management,not only the good running state and the accuracy of the test could be ensured,but aiso the life being prolong and the equipment maintenance costs being reduced.From the installation and runing environment,document information,reasonable use of the instrument,this gives some key points on the management of the new large laboratory instrument.