Abstract: The fundamentals of navigation is a basic course of specialty of detection guidance and control technology of University of Electronic Science and Technology of China (UESTC). This paper focused on the teaching reform of this course and introduced corresponding innovation reform measures in recent years. Firstly, an intensive study of the relationship between this curriculum and other courses is deeply studied. Secondly, the relationship between the key point of teaching content of this course and other professional courses is also studied, and some suggestions for other professional courses are put forward to the teachers. Aiming to the theoretical teaching reform, we give corresponding solutions to the teachers and the students from three aspects: focusing on solving the key and difficult points of teaching content, deleting and combing the duplicate content of the course, improving subject frontier knowledge. For experimental teaching reform, we have designed five kinds of comprehensive experiments for practice teaching, these experiments will help how to understand the course and other courses. Finally, according to the main difficulties in the course, the concrete improvement method was put forward.