Abstract: Biochemistry experiment is an important basic experiment course in clinical medicine. It plays an important role in improving the students’ operating skills and innovation abilities. But under the influence of the traditional teaching mode, there are still a series of disadvantages in the teaching contents, teaching methods, assessment methods as well as organization and management in class. To solve these problems, we did many tries and reformations in the experiment teaching procedures. The reform practice effectively developed the students’ learning initiative and innovation abilities. As a result, the experiment teaching quality had been effictively improved.