Abstract: With the chance of building national experimental teaching demonstration center of agricultural biotechnology,this paper gives research and practice of information management innovation in experiment teaching center under network condition from website establishment and continuous optimization,experiment teaching management,management of experiment equipments,management of the low-value consumables,management of instruments appointment,management of open laboratory,sharing resource of experiment teaching,team construction of informatization.And it integrates existing network resources,regulates management information platform of experiment teaching center,achieves automation,intelligence,opening and sharing of management,promotes the optimum use of resources,developes the students self-study ability,and fosters the students creative consciousness.