Abstract: With the rapid development of China's higher education“211 Project” and “985 Project” have been implemented,and a large number of national key laboratories have been established.In this paper,the new problems faced by the laboratory safety management in colleges and universities at present are analyzed,draws lessons from the management experience of colleges and universities at home and abroad.Combined with the present situation,explored how to transform the leap-forward development of the new situation,strengthen the laboratory safety management.Put forward some suggestions for work of laboratory safety management in colleges and universities.