Abstract: In order to improve students’ interest in learning,to cultivate their practical ability and innovation ability,the teaching system of physical chemistry open laboratory is constructed by combining the teaching practice of physical chemistry experiment of Huaihua college.In the paper,the selection of the experiment content design,experimental guidance method and management mode of open laboratory were discussed and practiced.Experience has proved that open laboratory can effectively utilize teaching resources and strengthen practice links,which is conducive to students’ autonomous learning and innovative ability training.