Abstract: The open laboratory of large scale instruments is an important place to train high level scientific research talents and innovative talents,and its safety management is an important guarantee for teaching and scientific research activities.Based on the practical experience of the key Laboratory of Leather Chemistry and Engineering of Ministry of Education,Sichuan University,the characteristics of opening-laboratory for large scale instruments were analyzed.In order to further improve and improve the safety management of laboratory,the special safety management model has been set up,and the effective measures and methods such as strengthening the training of the management personnel of the large instrument experimental technology,strengthening the safety consciousness of the experimental operators,equipping the safety emergency equipment,and perfecting the safety signs are put forward.