Abstract: Petroleum refining engineering is an important course for cultivating oil and gas chemical talents.According to the development trend of the industry in recent years and the requirements of engineering education,this paper combines the training of the talents of the school,starting from the course content teaching methods,practice links and assessment methods.Throughout the main line of“enhanced knowledge application and close to engineering practice”,the comprehensive reform of the curriculum was carried out in depth.quality,comprehensive reform based on promoting the application of knowledge and closing to the engineering practice was adopted for this course.The reform has been performed in the overall teaching process including teaching contents,methods,practical training and examination.More novel technologies used in industry were contained in the teaching contents.The teaching methods of case cycle and knowledge point connection were adopted to construct an engineering and comprehensive experimental project with small reaction device as the core.The evaluation methods based on the study of learning input and knowledge application ability were improved,which effectively improved the quality of engineering talent training.