Abstract: The physical chemistry experiment teaching is a very important curriculum for the cultivation of innovative and comprehensive talents in the field of chemistry and chemical engineering. In order to cultivate innovative comprehensive talents in the new period, by increasing the proportion of design experiments, heuristic teaching , increasing classroom interaction, increasing laboratory openness, improving scientific assessment standards and timely summing up feedback and other physical chemistry experimental teaching reform. Give full paly to the subjective initiative of the student subject. It has realized the transformation from "teaching-based" to "teaching and learning", and has greatly cultivated and improved students’ independent innovation ability, and promoted and strengthened the cultivation of innovative comprehensive talents.