Abstract: Aiming at the problems existing in the practice of software engineering courses at present, based on the college students’ software design competition, this paper proposes a method of driving industry-university cooperation synergy with the discipline competition mode. The reform and innovation of the software engineering comprehensive curriculum design highlights the quality training of students’ engineering ability and innovation ability with quality and innovation as the core. The connotation, realization approach and guarantee mechanism of collaborative training are discussed in depth. Finally, combined with the actual situation of teaching, the application effect of the method is illustrated.