Abstract: Under the premise of profound understanding of the connotation of innovation and entrepreneurship education, in response to the problems existing in traditional teaching, the teaching reform of the micro-computer control courses in the major mechanical majors was carried out. Using virtual simulation technology, effective exploration and practice have been carried out in the aspects of integration and optimization of course content, progressive setting of experimental projects, diversification of teaching methods and assessment methods. The results show that the teaching reform stimulates students' interest in learning, enhances students' self-learning ability, and cultivates and improves their hands-on ability and innovation and entrepreneurial ability.