Abstract: The main problems in the management of large-scale instrument sharing platform are analyzed. Combined with the development of current information technology, the role of information resources in the management of large-scale instrument sharing platform is discussed. Through the construction of the website, the introduction of the Internet of Things management system, the use of virtual simulation teaching resources, etc., the problems arising in the management of the current large-scale instrument sharing platform are solved, and the results of the new management model are investigated and analyzed. The results show that the utilization of information resources has improved the management efficiency of large-scale instrument sharing platforms and has been recognized by teachers and students.