Abstract: The practice teaching mode of chemical engineering cognition base has been reformed, which includes the following aspects. A cognitive logic of “total-division-total” teaching idea and content have been constructed relying on the existing teaching resources. The ideological and political theories education cases have been excavated and constructed. New teaching methods have been comprehensively adopted including multimedia, case discussion, learning committee/monitor leading, and self-learning by scanning QR code. The online learning test database is constructed, and the online classroom test method is developed to realize the digitalization of student evaluation. Practice shows that the reform increases students’ participation and interest in the curriculum and achieves a good teaching effect.