Abstract: As a place for cultivating applied and technical talents, university laboratories take responsibility in the fields of teaching and scientific research. Laboratory safety is the premise for all teaching activities and scientific research work to be carried out as scheduled. The laboratory management level directly affects the laboratory safety, practice achievement, and teaching quality. This paper focuses on the current situation and existing problems in the management of food science and engineering laboratories, and puts forward some safety management countermeasures, from the aspects of establishment and improvement of the safety supervision and management system, identifying potential security risks, and formulation of the scientific and reasonable emergency plans. Through the entity construction of the laboratory, some safety management countermeasures are put forward here with the aim to improve the scientific level of laboratory safety management.