Abstract: In the tradition of cloisonne enamel painting, it is mainly made by hand. The drawing speed is slow, and if low quality it will affect the artistic effect of the painting. So, it has great limitations. Laser processing technology has the characteristics of high precision, fast speed and high level of automation, and can be used in the production of cloisonne enamel painting. In this paper, the application method of laser processing technology in the production of cloisonne enamel painting is studied. Taking Wu Bing’s silk color painting “Hibiscus of Water” as an example, the process of manufacturing cloisonne enamel painting board using laser processing from design, debugging and processing to parameter setting is elaborated in detail, which provides ideas and references for the personalized customization and mass production of cloisonne enamel painting crafts in the future.